Last week I was at DIG London, in London, Ontario. It's normally a gaming conference, but they've added a web track and asked me to come speak. It was a fairly good experience, helped in part by their keynote, the infamous Jeffrey Zeldman talking about responsive design and related topics.
One of the points Zeldman made was that users want content their way, not the way we (web designers, web authors, and web devleopers) want it. Visually impared users want content read to them, or resized. Color blind users want a different color scheme that they can actually read. Smartphone users want content in a narrow column, without a dozen sidebar blocks. Mobile users want content offline, so they can read it on a plane. Many users want just the content, no design, and so use tools like Instapaper to strip out everything but the text of an article. RSS feeds have been around for a decade, and are now growing rapidly thanks to mobile devices, and those are generally (mostly) layout-free. If you're doing responsive design, then you're not making a design but the framework of a design that will change, and possibly mostly disappear, under certain circumstances.
Of course, that to me begs a very important question. When I asked it during Q&A, even Zeldman didn't have an answer. (Yes, I stumped the King of Web Standards. Woohoo!)
In the modern web, does web design even matter?